Classification of coagulation factors

 Classification of coagulation factors.

 

List of Blood clotting factors:

Coagulation factors number and nameDescription and originFunction
Plasma coagulation factors:  
factor I: FibrinogenPlasma protein synthesized in liver.Precursor of fibrin, converted to fibrin in final stage of clotting. Serum is plasma minus fibrinogen.
factor II: ProthrombinPlasma protein synthesized in liver. Synthesis requires vitamin K.Precursor of thrombin, the enzyme that converts fibrinogen into fibrin.
factor III: Thromboplastin Complex lipoprotein formed from disintegrating platelets or tissues.Combines with calcium to convert prothrombin into active thrombin.
factor IV: Calcium ionsInorganic ion in plasma, acquired from bones and diet.Essential for formation of thrombin and for all stages of clotting
factor V: Proaccelerin, labile factor, or accelerator globulinPlasma protein synthesized in liver.Necessary for extrinsic and intrinsic pathways
factor VINo longer thought to be a separate entity, possibly the same as factor V. 
factor VII: Serum prothrombin conversion accelerator (SPCA), stable factor or proconvertinPlasma protein synthesized in liver. Synthesis requires vitamin K.Necessary for first phase of extrinsic pathway.
facor VIII: Antihemophilic factor (AHF), antihemophilic factor A, or antihemolytic globulin (AHG)Plasma protein synthesized in liver and other tissues.Necessary for first phase of intrinsic pathway. Deficiency causes hemophilia A, genetic disorder
factor IX: Plasma thromboplastin component (PTC), Christmas factor, or antihemophilic factor BPlasma protein synthesized in liver. Synthesis requires vitamin K.Necessary for first phase of intrinsic pathway. Deficiency causes hemophilia B.
factor X: Stuart-Prower factor or Stuart factorPlasma protein synthesized in liver. Synthesis requires vitamin K.Necessary for early phases of extrinsic and intrinsic pathways.
factor XI: Plasma thromboplastin antecendent (PTA) or antihemophilic factor CPlasma protein synthesized in liver.Necessary for first phase of intrinsic pathway. Deficiency causes hemophilia C.
factor XII: Hageman factor or glass factorPlasma protein, source unknown.Necessary for first phase of intrinsic pathway, activates plasmin, activated by contact with glass, probably involved with clotting outside body.
factor XIII: Fibrin-stabilizing factor (FSF) or Larki-Lorand factorProtein present in plasma and platelets, source unknown.Necessary for final phase of clotting.


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