Haemostatic Mechanism (Clotting Mechanism)
Blood Clotting: Factors, Mechanism
Hemostasis mechanism of preventing blood loss
- One drawback of a circulatory system such as ours, in which the liquid blood is under high pressure, is that serious bleeding can take place after even a slight injury.
- To prevent the possibility of uncontrolled bleeding, we have a three-part hemostatic mechanism consisting of:
- The constriction of blood vessels
- The clumping together (aggregation) of platelets
- Blood clotting
- Overall, hemostasis is a specific type of homeostasis that prevents blood loss.
1. Vasoconstrictive phase:
- Normally, when a tissue is damaged and blood escapes from a blood vessel, the vessel wall constricts in order to narrow the opening of the vessel and slow the flow of blood.
- This vasoconstriction is due to contraction of the smooth muscle of the vessel wall as a direct result of the injury and the release of vasoconstrictor chemicals from platelets.
- Proper vasoconstriction is also enhanced by pain reflexes, producing constriction in proportion to the extent of the injury.
- Constriction of capillaries, which donot have muscular layers, is due to the vascular compression caused by the pressure of lost blood that accumulates in surrounding tissues.
- Injured blood vessels may continue to constrict for 20 min or more.
2. Platelet phase:
- The next event in hemostasis is the escape from blood vessels of platelets, which swell and adhere to the collagen in adjacent connective tissues.
- This attachment stimulates vasoconstriction.
- By now, the platelets have become very sticky, so that as more and more of them move into the injured are they stick together.
- In about a minute they can clog a small opening in the vessel with a platelet plug.
- The process is called platelet aggregation.
- It is important partly because it successfully stops hundreds of small hemorrhages every day and partly because it triggers the blood-clotting mechanism.
3. Coagulation phase: Basic mechanism of blood clotting
- If the blood vessel damage is so extensive that the platelet plug cannot stop the bleeding, the complicated process of blood clotting- the coagulation phase- begins.
- The basic clotting mechanism involves the following events:
- Supported by a plasma globulin called antihemophilic factor (AHF), blood platelets disintegrate and release the enzyme thromboplastinogenase and platelet factor 3.
- Thromboplastinogenase combines with AHF to convert the plasma globulin thromboplastinogen into the enzyme thromboplastin.
- Thromboplastin combines with calcium ions to convert the inactive plasma protein prothrombin into the active enzyme thrombin.
- Thrombin acts as a catalyst to convert the soluble plasma protein fibrinogen (‘giving birth to fibrin’) into the insoluble, stringy plasma protein fibrin.
- The fibrin threads entangle the blood cells and create a clot.
- The basic process may be summarized as follows:
- Thromboplastinogen —–Thromboplastinogenase+ antihemophilic factor——-> Thromboplastin
- Prothrombin ——-Thromboplastin+ calcium ions-——-> Thrombin
- Fibrinogen ——thrombin————> Fibrin
List of Blood clotting factors:
Coagulation factors number and name | Description and origin | Function |
Plasma coagulation factors: | ||
factor I: Fibrinogen | Plasma protein synthesized in liver. | Precursor of fibrin, converted to fibrin in final stage of clotting. Serum is plasma minus fibrinogen. |
factor II: Prothrombin | Plasma protein synthesized in liver. Synthesis requires vitamin K. | Precursor of thrombin, the enzyme that converts fibrinogen into fibrin. |
factor III: Thromboplastin | Complex lipoprotein formed from disintegrating platelets or tissues. | Combines with calcium to convert prothrombin into active thrombin. |
factor IV: Calcium ions | Inorganic ion in plasma, acquired from bones and diet. | Essential for formation of thrombin and for all stages of clotting |
factor V: Proaccelerin, labile factor, or accelerator globulin | Plasma protein synthesized in liver. | Necessary for extrinsic and intrinsic pathways |
factor VI | No longer thought to be a separate entity, possibly the same as factor V. | |
factor VII: Serum prothrombin conversion accelerator (SPCA), stable factor or proconvertin | Plasma protein synthesized in liver. Synthesis requires vitamin K. | Necessary for first phase of extrinsic pathway. |
facor VIII: Antihemophilic factor (AHF), antihemophilic factor A, or antihemolytic globulin (AHG) | Plasma protein synthesized in liver and other tissues. | Necessary for first phase of intrinsic pathway. Deficiency causes hemophilia A, genetic disorder |
factor IX: Plasma thromboplastin component (PTC), Christmas factor, or antihemophilic factor B | Plasma protein synthesized in liver. Synthesis requires vitamin K. | Necessary for first phase of intrinsic pathway. Deficiency causes hemophilia B. |
factor X: Stuart-Prower factor or Stuart factor | Plasma protein synthesized in liver. Synthesis requires vitamin K. | Necessary for early phases of extrinsic and intrinsic pathways. |
factor XI: Plasma thromboplastin antecendent (PTA) or antihemophilic factor C | Plasma protein synthesized in liver. | Necessary for first phase of intrinsic pathway. Deficiency causes hemophilia C. |
factor XII: Hageman factor or glass factor | Plasma protein, source unknown. | Necessary for first phase of intrinsic pathway, activates plasmin, activated by contact with glass, probably involved with clotting outside body. |
factor XIII: Fibrin-stabilizing factor (FSF) or Larki-Lorand factor | Protein present in plasma and platelets, source unknown. | Necessary for final phase of clotting. |
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