Histo Case Study
Case study:-
A 25-year-old
woman presented to her primary care physician with a one-week history of
blurred vision in her left eye. She stated that it was painful to move that
eye. She grew up in Minnesota and has smoked one-half of a pack of
cigarettes/day for the last 7 years. Further questioning reveals that she had
unilateral tingling on her left side in the two weeks before her wedding 3
years ago. CSF analysis showed mildly elevated protein and moderate
pleocytosis. MRI revealed multiple hypointense lesions and FLAIR
(fluid-attentuated inversion recovery) MRI showed multiple supratentorial
lesions. When the patient learned of her possible diagnosis, she returned home
and took an overdose of sleeping pills. Gross and microscopic images of the
autopsy are provided.
Image Gallery:
3. 
MRI shows
multiple white matter lesions in the corpus callosum, subcortical U-fibers,
temporal lobes, brainstem, cerebellum and spinal cord.
Grossing shows ,
multiple well circumscribed somewhat depressed lesions in the white matter. A
coronal section through the cerebrum has been stained with luxol fast
blue/hematoxylin and eosin which stains the myelinated white matter blue and
the cortex pink. There are multiple plaques of demyelination.
By observing all
these finding explain that patient is suffering from which condition. What is
the differential diagnosis? What could be the reason of lesion?What type of
stain is suggested by the pathologist?
https://docs.google.com/document/d/1lVewPuqhhwApbffth3CL0y_YfamUyynx2l6goz_Avvo/edit?usp=sharing
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